Exosomes are microscopic extracellular vesicles (containers) naturally released by cells throughout the body. Think of them as high-speed cellular messengers. They travel between cells to deliver a complex mixture of growth factors, proteins and messenger molecules involved in cellular communication.
Skin ageing is not caused by a single factor. Instead, it develops through a combination of collagen loss, chronic low-grade inflammation, oxidative stress, reduced cellular communication, environmental damage, and slower tissue repair.
Exosomes help address these processes by delivering signalling molecules that encourage surrounding cells to function more efficiently, support tissue repair, and promote healthier cellular activity.
Growth factors help support fibroblast activity, encouraging the skin to rebuild structural proteins essential for firmness and elasticity. This helps improve skin firmness and elasticity, refine skin structure, and reduce the appearance of fine lines and early skin laxity.
Anti-inflammatory molecules help regulate pathways associated with redness, acne and chronic inflammation. This leads to reduced redness, improved recovery from acne flare-ups, and healthier-looking skin.
Exosomes support skin barrier repair and cellular health, helping the skin retain moisture more effectively while strengthening its protective function. This results in improved hydration, reduced sensitivity, and healthier overall skin quality.
Following aesthetic procedures such as laser treatments or radiofrequency microneedling, Exosomes help optimise the skin’s natural healing response. This supports faster recovery, reduced downtime, and improved post-procedure healing.
Support fibroblast activity, encouraging the production of collagen and elastin.
Facilitate cellular communication to optimise the skin's natural repair response.
Retain moisture more effectively while strengthening its protective function to support skin barrier and cellular health.
Contain anti-inflammatory signalling molecules that help regulate inflammatory pathways.
Exosomes are large molecules and they cannot easily penetrate intact skin on their own. To optimise delivery into the skin, Exosomes needs to be paired with treatments that create temporary micro-channels, allowing regenerative signalling molecules to reach deeper skin layers.
The procedure is executed in two synchronized, highly precise phases:
Also known as our Skin Revitalisation Protocol, Morpheus8 RF Microneedling delivers radiofrequency energy into the deeper layers of the skin, followed by application of Exosomes to enhance collagen remodelling process, improve skin firmness, and support post-treatment redness and recovery.
Pico Laser creates microchannels to stimulate collagen production, exosomes are then applied to support recovery, calm inflammation and regulate pigment-related pathways, resulting in brighter, more even-toned skin with reduced redness, accelerated healing and improved overall radiance.
Pairing CO2 Laser and Exosomes helps stimulate collagen remodelling and skin renewal, support recovery, calm inflammation and optimise the skin's natural healing response, resulting in faster healing, reduced downtime, improved skin texture and smoother, healthier-looking skin.
| Timeline | What Happens In The Skin | What Patients May Notice |
|---|---|---|
| Immediately After Treatment | Exosomes begin interacting with surrounding skin cells and supporting the skin’s natural recovery response. | Mild redness, warmth. |
| First 1-3 Days | Skin barrier recovery and early anti-inflammatory signalling processes begin. | Reduction in redness, calmer skin appearance, improved hydration, and early post-treatment glow. |
| Week 1 | Early cellular repair and tissue recovery continue while inflammation gradually subsides. | Skin may appear smoother, brighter, and more refreshed. Many patients notice improved skin softness and hydration. |
| Weeks 2–4 | Fibroblast activity and collagen stimulation pathways become more active, especially when combined with microneedling or laser treatments. | Early subtle improvements in skin radiance, pore appearance, and overall skin quality. |
While many retail beauty brands have recently introduced “exosome-infused” creams and serums for home use, there is a significant difference between over-the-counter cosmetics and exosomes in clinic. True exosomes can never be packaged into a standard bottle of retail skincare for several critical scientific reasons.
The skin’s outer protective barrier is naturally engineered to block large molecules from entering. Exosomes cannot effectively pass through intact skin on its own simply by being applied on. They require clinical micro-channelling technologies (such as RF Microneedling or Lasers). This medical-grade gateway can only be safely created in a professional clinic setting.
Exosomes, especially human-derived exosomes, are highly delicate products. In a standard cosmetic cream or serum sitting on a retail shelf at room temperature, real exosomes would degrade and lose clinical potency within a matter of days. To maintain their biological activity, they must undergo a freeze-drying process and be stored in sterile, temperature-controlled vials. They are only reconstituted with a sterile, nourishing activator by an aesthetic doctor immediately before your clinical procedure.
The HSA regulates health and cosmetic products under world-class, rigorous standards. Under local regulations, exosomes are designated as professional medical treatments. Authentic, clinical-grade exosome treatments must only be delivered under medical supervision within a licensed facility using approved medical-grade delivery devices, ensuring maximum patient safety and treatment transparency.
Our team will go through a registration process with you to collect basic details and understand your skin concerns.
Your skin is thoroughly cleansed to remove makeup, oil, and impurities to prepare the skin for treatment.
Photos are taken to document your current skin condition and referenced during the doctor’s consultation.
A topical numbing cream is applied to minimise discomfort during the procedure.
Our doctor will discuss your concerns, goals, and medical history to ensure the treatment is tailored to your needs.
Your customised treatment creates micro channels in the skin surface, temporarily increasing the skin’s permeability.
The booster is applied topically while the microchannels are still open, allowing the solution to penetrate deeply.
A calming sheet mask is applied o soothe the skin. Our team will advise you on what to do and expect in the next few days.
Yes. Under Health Sciences Authority (HSA) guidelines, Exosomes are approved for topical application use. At Astria, we safely deliver them topically through medically controlled micro-channels (Morpheus8 RF Microneedling or Lasers) to help optimise treatment delivery while maintaining high standards of patient safety.
Since exosomes are applied topically, the infusion itself is completely painless and highly soothing. The micro-channelling step (such as Pico Laser or RF Microneedling) might feel like fine pinpricks, but most patients find it tolerable. To ensure a comfortable experience, Astria also provides medical grade numbing cream prior to the treatment.
Yes. Patients with sensitive or reactive skin can benefit from the anti-inflammatory and skin barrier-supportive properties associated with exosome therapy. However, it is always best to schedule a consultation with our doctors so that your skin can be properly assessed.
Because exosomes contain signalling molecules that help regulate inflammation and support skin recovery, you may notice post-treatment redness settles more quickly. A mild, pinkish flush (resembling a very light sunburn) is normal, but this typically completely resolves within 24 hours.
No, they do not. Exosomes do not add volume or physically change facial contours. Their role is to support skin repair, collagen remodelling, and overall skin quality improvement, resulting in more natural-looking skin rejuvenation.
Yes! While exosomes cannot stop the natural ageing process, they are incorporated into treatment protocols to support healing and optimise the regenerative response following procedures. This may help patients achieve better overall skin quality and maximise the benefits of their aesthetic treatments.
Singapore’s climate presents unique challenges that accelerate skin ageing and inflammation, including year-round UV exposure, high humidity, heat-induced inflammation, and environmental pollution. Exosome therapy helps by supporting skin recovery, regulating inflammation, and improving skin resilience alongside traditional anti-ageing benefits.
Whether you have questions about our treatments, want to book an appointment, or simply like to learn more about how we can help you achieve your skin goals, our team is here to assist!
Astria Medical Aesthetics believes in a sustainable aesthetic journey. Beauty can be a continuous, timeless goal.
51 Bras Basah Road, #04-06A
Lazada One, Singapore 189554
OPENING hours
Monday – Friday
10.30am – 8.30pm
Saturday
10.30am – 6.30pm
Sun & PH closed
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